Selected Publications
May 29, 2019
Pleiotropic Roles of Cytokines in HIV-1 Pathogenesis and Control: A Literature Review
Hamidzada, H., & Guzzo, C. (2019). Pleiotropic Roles of Cytokines in HIV-1 Pathogenesis and Control: A Literature Review. Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal, 3 (5), 1-10. doi:10.26685/urncst.128
January 20, 2019
The Incorporation of Host Proteins into the External HIV-1 Envelope
Burnie, J., & Guzzo, C. (2019). The Incorporation of Host Proteins into the External HIV-1 Envelope. Viruses, 11 (1), 85. doi:10.3390/v11010085
December 11, 2018
Structural Constraints at the Trimer Apex Stabilize the HIV-1 Envelope in a Closed, Antibody-Protected Conformation
Guzzo, C., Zhang, P., Liu, Q., Kwon, A. L., Uddin, F., Wells, A. I., . . . Lusso, P. (2018). Structural Constraints at the Trimer Apex Stabilize the HIV-1 Envelope in a Closed, Antibody-Protected Conformation. MBio,9(6). doi:10.1128/mbio.00955-18
July 13, 2017
Design of HIV Coreceptor Derived Peptides That Inhibit Viral Entry at Submicromolar Concentrations.
Design of HIV Coreceptor Derived Peptides That Inhibit Viral Entry at Submicromolar Concentrations. Bobyk KD, Mandadapu SR, Lohith K, Guzzo C, Bhargava A, Lusso P, Bewley CA. Mol Pharm. 2017 Jul 13. doi: 10.1021/acs.molpharmaceut.7b00155. [Epub ahead of print]
July 2017
IL-27 enhances LPS-induced IL-1β in human monocytes and murine macrophages.
IL-27 enhances LPS-induced IL-1β in human monocytes and murine macrophages. Petes C, Wynick C, Guzzo C, Mehta D, Logan S, Banfield BW, Basta S, Cooper A, Gee K. J Leukoc Biol. 2017 Jul;102(1):83-94. doi: 10.1189/jlb.3A0316-098R. Epub 2017 Apr 4.
May 12, 2017
Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing.
Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing. Guzzo C, Ichikawa D, Park C, Phillips D, Liu Q, Zhang P, Kwon A, Miao H, Lu J, Rehm C, Arthos J, Cicala C, Cohen MS, Fauci AS, Kehrl JH, Lusso P. Sci Immunol. 2017 May 12;2(11). pii: eaam7341. doi: 10.1126/sciimmunol.aam7341.
April 2017
Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer.
Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer. Liu Q, Acharya P, Dolan MA, Zhang P, Guzzo C, Lu J, Kwon A, Gururani D, Miao H, Bylund T, Chuang GY, Druz A, Zhou T, Rice WJ, Wigge C, Carragher B, Potter CS, Kwong PD, Lusso P. Nat Struct Mol Biol. 2017 Apr;24(4):370-378. doi: 10.1038/nsmb.3382. Epub 2017 Feb 20.
August 2016
Tyrosine-sulfated V2 peptides inhibit HIV-1 infection via coreceptor mimicry
Tyrosine-sulfated V2 peptides inhibit HIV-1 infection via coreceptor mimicry. Cimbro R, Peterson FC, Liu Q, Guzzo C, Zhang P, Miao H, Van Ryk D, Ambroggio X, Hurt DE, De Gioia L, Volkman BF, Dolan MA, Lusso P. EBioMedicine. 2016 Aug;10:45-54. doi: 10.1016/j.ebiom.2016.06.037. Epub 2016 Jun 26.
November 20, 2015
Engineering Metamorphic Chemokine Lymphotactin/XCL1 into the GAG-Binding, HIV-Inhibitory Dimer Conformation.
Engineering Metamorphic Chemokine Lymphotactin/XCL1 into the GAG-Binding, HIV-Inhibitory Dimer Conformation. Fox JC, Tyler RC, Guzzo C, Tuinstra RL, Peterson FC, Lusso P, Volkman BF. ACS Chem Biol. 2015 Nov 20;10(11):2580-8. doi: 10.1021/acschembio.5b00542. Epub 2015 Sep 2.
September 2015
Structural Determinants for the Selective Anti-HIV-1 Activity of the All-β Alternative Conformer of XCL1.
Structural Determinants for the Selective Anti-HIV-1 Activity of the All-β Alternative Conformer of XCL1. Guzzo C, Fox JC, Miao H, Volkman BF, Lusso P. J Virol. 2015 Sep;89(17):9061-7. doi: 10.1128/JVI.01285-15. Epub 2015 Jun 17.
April 2, 2015
Characterization of HIV-1 entry inhibitors with broad activity against R5 and X4 viral strains.
Characterization of HIV-1 entry inhibitors with broad activity against R5 and X4 viral strains. Sironi F, Malnati M, Mongelli N, Cozzi P, Guzzo C, Ghezzi S, Martínez-Romero C, García-Sastre A, Lusso P, Jabes D, Biswas P. J Transl Med. 2015 Apr 2;13:107. doi: 10.1186/s12967-015-0461-9.
February 25, 2014
Tyrosine sulfation in the second variable loop (V2) of HIV-1 gp120 stabilizes V2-V3 interaction and modulates neutralization sensitivity.
Tyrosine sulfation in the second variable loop (V2) of HIV-1 gp120 stabilizes V2-V3 interaction and modulates neutralization sensitivity. Cimbro R, Gallant TR, Dolan MA, Guzzo C, Zhang P, Lin Y, Miao H, Van Ryk D, Arthos J, Gorshkova I, Brown PH, Hurt DE, Lusso P. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3152-7. doi: 10.1073/pnas.1314718111. Epub 2014 Feb 3.
December 2013
The CD8-derived chemokine XCL1/lymphotactin is a conformation-dependent, broad-spectrum inhibitor of HIV-1.
The CD8-derived chemokine XCL1/lymphotactin is a conformation-dependent, broad-spectrum inhibitor of HIV-1. Guzzo C, Fox J, Lin Y, Miao H, Cimbro R, Volkman BF, Fauci AS, Lusso P. PLoS Pathog. 2013;9(12):e1003852. doi: 10.1371/journal.ppat.1003852. Epub 2013 Dec 26.
November 2012
The TLR2 agonists lipoteichoic acid and Pam3CSK4 induce greater pro-inflammatory responses than inactivated Mycobacterium butyricum.
The TLR2 agonists lipoteichoic acid and Pam3CSK4 induce greater pro-inflammatory responses than inactivated Mycobacterium butyricum. Gambhir V, Yildiz C, Mulder R, Siddiqui S, Guzzo C, Szewczuk M, Gee K, Basta S. Cell Immunol. 2012 Nov;280(1):101-7. doi: 10.1016/j.cellimm.2012.12.001. Epub 2012 Dec 19.
December 2012
IL-27 increases BST-2 expression in human monocytes and T cells independently of type I IFN.
IL-27 increases BST-2 expression in human monocytes and T cells independently of type I IFN. Guzzo C, Jung M, Graveline A, Banfield BW, Gee K. Sci Rep. 2012;2:974. doi: 10.1038/srep00974. Epub 2012 Dec 13.
September 25, 2012
IL-27-induced gene expression is downregulated in HIV-infected subjects.
Guzzo, Christina, et al. “IL-27-Induced Gene Expression Is Downregulated in HIV-Infected Subjects.” PLoS ONE, vol. 7, no. 9, 2012, doi:10.1371/journal.pone.0045706.
January 15, 2012
IL-27 enhances LPS-induced proinflammatory cytokine production via upregulation of TLR4 expression and signaling in human monocytes.
IL-27 enhances LPS-induced proinflammatory cytokine production via upregulation of TLR4 expression and signaling in human monocytes. Guzzo C, Ayer A, Basta S, Banfield BW, Gee K. J Immunol. 2012 Jan 15;188(2):864-73. doi: 10.4049/jimmunol.1101912. Epub 2011 Dec 7.
October 21, 2011
Neu1 sialidase and matrix metalloproteinase-9 cross-talk is essential for Toll-like receptor activation and cellular signaling.
Neu1 sialidase and matrix metalloproteinase-9 cross-talk is essential for Toll-like receptor activation and cellular signaling. Abdulkhalek S, Amith SR, Franchuk SL, Jayanth P, Guo M, Finlay T, Gilmour A, Guzzo C, Gee K, Beyaert R, Szewczuk MR. J Biol Chem. 2011 Oct 21;286(42):36532-49. doi: 10.1074/jbc.M111.237578. Epub 2011 Aug 26.
April 2011
Interleukin-23-induced interleukin-23 receptor subunit expression is mediated by the Janus kinase/signal transducer and activation of transcription pathway in human CD4 T cells.
Interleukin-23-induced interleukin-23 receptor subunit expression is mediated by the Janus kinase/signal transducer and activation of transcription pathway in human CD4 T cells. Che Mat NF, Zhang X, Guzzo C, Gee K. J Interferon Cytokine Res. 2011 Apr;31(4):363-71. doi: 10.1089/jir.2010.0083. Epub 2010 Dec 7.
August 2010
Thymoquinone-induced Neu4 sialidase activates NFκB in macrophage cells and pro-inflammatory cytokines in vivo.
Thymoquinone-induced Neu4 sialidase activates NFκB in macrophage cells and pro-inflammatory cytokines in vivo. Finlay TM, Abdulkhalek S, Gilmour A, Guzzo C, Jayanth P, Amith SR, Gee K, Beyaert R, Szewczuk MR. Glycoconj J. 2010 Aug;27(6):583-600. doi: 10.1007/s10719-010-9302-5. Epub 2010 Aug 10.
August 6, 2010
Interleukin-27 induces a STAT1/3- and NF-kappaB-dependent proinflammatory cytokine profile in human monocytes.
Interleukin-27 induces a STAT1/3- and NF-kappaB-dependent proinflammatory cytokine profile in human monocytes. Guzzo C, Che Mat NF, Gee K. J Biol Chem. 2010 Aug 6;285(32):24404-11. doi: 10.1074/jbc.M110.112599. Epub 2010 Jun 2.